There was a similar thread a while back, but I can't find it. Anyway.

A Road Runner game, where you can play as both the RR and Wile E Coyote. RR tries to avoid the Coyote's traps, while he sets them. Finally, the Coyote can win. It should have a multiplayer mode, obviously, with teams of RRs and WE Coyotes. Both the RR and the Coyote can die in cartoony ways.

A Loony Tunes-themed fighting game, also with cartoony alities.

A first or third-person shooter starring Lobo. It can even be a 2D platform game. It should definitely be M-rated.

An Alien, Predator, or AVP game, whether it's a fighting one, a FPS, anything really.

Sequels to Primal Rage and Mace: The Dark Ages.