rvd in wwe smackdown games
ibuki in street fighter 3rd strike
ash crimson in king of fighters x1
testament in guilty gear series
taki in soul calibur series
lili in tekken series
scorpion in mk games

and so many more.

Keeping it Simple:

Stryker MK
Doctor Nefarious R&C
Garuda, Akuma SF
K' FoF
Bob, Bryan Fury. Tekken
MINION, Sweet Tooth, Darktooth, Manslaughter, Spectre TM

Mortal Kombat aside (I like so many of the characters) I'd say Sweet Tooth from Twisted Metal Black. So badass.

No other video game characters have really held my interest much, so many are the generic 'badass' hero types and a lot of them even look the same.

Mortal Kombat: Sindel, Jade, Kitana, Mileena

Dead or Alive: Helena, Christie, Leifang

Soul Calibur: Setsuka, Tira

Blazblue: Rachel

Mario Franchise: Princess Peach

Mortal Kombat: Ermac
Street Fighter: Akuma or Cammy
Marvel vs Crapcom: Akuma
Resident Evil: Albert Wesker
Killzone: Radec
Uncharted: Drake
Call of Duty: Dempsy
Tekken: Eddy Gordo
Aliens vs Predator: ANY Predator
Sonic Adventure 2 Battle (THIS GAME NEEDS A SERIOUS REMAKE!): Shadow the Hedgehog.
inFamous: Evil Cole

Solid Snake, Big Boss, Otacon, Psycho Mantis, Raiden - MGS Series

Jak, Sig - Jak and Daxter Series

Wander, Agro - Shadow of the Colossus

Simple and neat my friends.

One(or 2) characters from each series: Super Mario Bros.: Mario/Yoshi/Boo/Shy Guy
Crash/Ripper Roo
MK: Sub-Zero
Sonic/Shadow
Saints Row: Johnny Gat
Kirby/Metaknight
Earthbound(Mother): Ness
Kingdom Hearts: Sora/Riku/Mickey

I'll come up with more

Mortal Kombat
-Kenshi (as if you don't know what he looks like already..)
Resident Evil
-Billy Coen (Resident Evil 0)
Silent Hill
-Harry Mason
The Elder Scrolls II: Daggerfall
-Mannimarco, The King of Worms
Tekken
-Sergei Dragunov
Soul Calibur
-Setsuka

MK: Kabal
SF: Dudley
Red Dead Redemption: John Marston

Any character I create.

Aww. Thanks. :)

Reptile, Kitana and Shang Tsung from MK games

Revolver Ocelot from the Metal Gear games.

Laughing Octopus and Screaming Mantis from Megal Gear Soilid 4

Psycho mantis from MGS1

Magneto, Trish and Taskmaster from MvsC3

Many more i cant think of now lolol

Best character ever = GLADOS from Portal 1 & 2

Honorable mention: Dizzy from Gears of War, Ellis from Left for Dead (Jeeez, I got a thing for rednecks), Myself in Fifa

Mortal Kombat: Fujin & Kitana.

Carmageddon: Screwie Lewie, Val Hella & Stella Stunna.

Jak & Daxter: Daxter, Pecker, Vin & Jak.

Sly Cooper: Sly Cooper.

Ratchet & Clank: Clank.

Soul Calibur: Kilik & Setsuka.

Street Fighter: M. Bison, Rose, Guy & Chun-Li.

Tekken: Baek Doo San.

Worms: Holy Hand Grenade.

^^ Dude, seriously...everyone knows the mumbling granny or super sheep is the star of that game

Also love the holy handgrenade though.

Can I get a " Haaaaaaaaleyuyyyaaaa!"

Mortal Kombat: Scorpion

Assassin's Creed: Altair

GTA: Niko Bellic

Halo: Master Chief

CODMW: Griggs/Gaz

CODWAW: Reznov

Twisted Metal: Minion

Mass Effect: Garrus

Mortal Kombat: Stryker, Sonya, Rain,and Sheeva

Soul Calibur: Raphael,Talim, Yun-Seung, Xiangua

Resident Evil: Leon Kennedy, Sheva Alomar, Chris Redfield

Sonic The Hedgehog: Sonic, Tails, Knuckles, Amy, Espio, Rouge

Tatsunoko v.s. Capcom: Yatterman 2, Frank West, Viewtiful Joe.

Gauntlet Dark Legacy: The Knight, The Sorceress, The Green Jester lol.

Mortal Kombat: Stryker, Liu Kang & Nightwolf
Oddworld: Abe & the Sligs
Twisted Metal: Mr.Slam, Hammerhead & Sweet Tooth
Crash Bandicoot: Crash, N.Gin, Tiny & Neo Cortex
Spyro The Dragon: Spyro & Hunter
Silent Hill: Harry Mason
Resident Evil: Leon, Barry, Wesker & the Merchant from RE4
Tekken: Eddy, King, Bryan, Jin, Lei, Law & Jun
honorable mentions go to Rayman, Lara Croft, Gex & Gabe Logan

jade, kitana, mileena, male ninjas, sonya

nina, anna, jun, law, eddy

sarah, jacky, pai, Lau, kage

ryu, ken, akuma, cammy, chun-li

orchid, fulgore, spinal, sabrewolf, tj combo

Mortal Kombat: Frost, Moloch, Daegon.
Dead of Alive: Kokoro, Lei Fang, Lisa.
Street Fighter: Crimson Viper, Ibuki, Makoto.
Soul Calibur: Tira, Ivy Valentine, Xianghua.
Tekken: Zafina, Kunimitsu, Unknown.
Zelda: Princess Zelda/Sheik, Tetra, Toon Link.
Sonic: Knuckles, Rouge, Tikal.
Rival Schools: Zaki, Akira, Kyoko,
Mario: Rosalina, Daisy, Toadette/Wario (Tie).
Virtua Fighter: Eileen, Pai Chan, Aoi Umenokouji.

Street Fighter: Adon, Yang, Dee Jay, Hakan, Chun-Li, Juri, Cammy

Mortal Kombat: Fujin, Jade

Pokemon: Cloyster, Honchkrow, Swampert, Raikou, Elesa

That's pretty much all I play

Got more to add....

Mortal Kombat:Scorpion,Smoke,Sub Zero and Kitana

Assassins Creed:Ezio(Thats obvious lol)

Marvel vs Capcom,since you pic three:Deadpool,Wolverine,Ryu

Street Fighter:Vega

WWE:RVD,CM Punk

X-Men Origins Wolverine:Classic Wolverine

Marvel Ultimate Alliance(2):Deadpool,Wolverine,Spider Man and Hulk

(I just added four more games)

Whaaaaaa?!!

Holy Hand Grenade is the most epic one!

Flying Sheep was crazy too! The granny was funny, but not that useful though.

Ming Vase was ridiculous though, that one could blow up half the stage, at least in Worms 2 on PC.